New! Dynamic Kinetic Simulation and Global Data Fitting Software
For PC, MAC and Linux

Two papers are in press describing the new software.

Click here to go directly to download options

Features...

• Simple, intuitive user interface: Enter new models in simple E + A = EA = EI = EP = E + P format, with instant feedback to highlight errors while you type.
• Dynamic simulation: Scroll rate constants, starting concentrations and output factors while viewing changes in the shape of the graph .
• Robust data fitting routines: Perform nonlinear regression based upon the simulation model, not mathematical approximations to reality.
• Global Fitting of multiple experiments: Simultaneously fit multiple experiments performed under different starting conditions.
• Exploration using linked or fixed rate constants: Fix individual constants or link two or more rate constants to vary in unison while dynamically scrolling and fitting data.

POWERFUL ◊ DYNAMIC ◊ EASY TO USE ◊ INTUITIVE ◊ FAST ◊ GLOBAL DATA FITTING

Screenshot showing global fitting of four experiments, with FitSpace visualization in the top right corner.

Benefits...

The Fast Dynamic Simulation and Intuitive user interface make it easy to compare multiple models and to explore relationships between the kinetic parameters and the observable outputs. Seeing the curves change in shape as you scroll a rate constant or starting concentration provides immediate feedback to learn kinetics, evaluate models, and explore whether any constant is determined by the data. Moreover, Global Data Fitting directly to the model eliminates the tedious and error-prone analysis using conventional methods that depend upon fitting to simplified mathematical models. Simultaneously fitting multiple experiments constrains the fit and ensures that the model quantitatively accounts for all of the data, and the ability to link or fix rate constants further ensures that the fitting of data to the model is sufficiently constrained to be meaningful.

KinTek Global Kinetic Explorer offers unprecedented power to design and rigorously interpret experiments to fully unleash your creative potential!

Advantages of Fitting Data Directly to the Model by Simulation

			Conventional data fitting requires simplifying assumptions to allow mathematical solutions of equations describing a chosen model, followed by fitting to analytical functions, replotting of observed rates and extraction of rate constants according to the assumed model. With the release of KinTek Global Kinetic Explorer, conventional methods of data fitting are obsolete! Fitting data directly to the model based upon simulation is both easier and more accurate. In the New Enzymology, even steady state data should be fit globally to the model, bypassing the steady state assumption and all of the equations. Benefits of Global Data Fitting Faster and more accurate fitting No simplifying assumptions No errors in deriving equations No need for pseudo-first order conditions Alternative models can be evaluated Dynamic simulation gives feedback

Licenses for KinTek Global Kinetic Explorer can be purchased from KinTek Corporation, www.kintek-corp.com

New Features in Version 2.0 of KinTek Kinetic Explorer

FitSpace Explorer: Given the power and ease of use of KinTek Explorer, it is too easy to enter an overly complex model and often difficult to evaluate whether the model and the rate constants are actually determined by the data. Conventional error analysis fails miserably to notify you when your model is under-constrained. Therefore, it is difficult to evaluate the extent to which the fit and the model are constrained by the data especially when fitting multiple parameters to multiple data sets simultaneously. FitSpace Explorer solves these problems by exploring the range over which parameters can vary and still achieve a good fit to the data. This analysis provides more realistic estimates of errors on fitted parameters than are obtained by conventional nonlinear regression covariance analysis
No more Reverse Polish Notation: Entry of output expressions now uses the more familiar infix notation. The first time you load an old mechanism file created under Version 1, you will be required to convert your output expression to infix notation. This is explained in more detail under Experiment Editor.
Rate vs Concentration Plot: You can fit your data to analytic functions in the old-fashioned way and if you have a series of traces collected at several concentrations, you can click on Rate v. Conc and see the a graph of the concentration dependence of the observed rates. This is useful in revealing patterns in the data that suggest the underlying mechanism.
Faster Execution: Improvements in the integrator make fitting and scrolling more than 10-fold faster! Also, the user no longer enters the number of points to simulate; rather, the integrator optimizes the step-size during simulation.
Double Precision: All calculations are now done in double precision (64-bit).
Video Projection Mode: When working with a small portable computer or during video projection, the screen resolution is limited and that may make the graph too small relative to the control panel. You can toggle the control panel on/off by pressing Ctrl-D to see the graph on the full screen. If you start to scroll a value before pressing Ctrl-D, you can continue scrolling. You can also use the Display Model to scroll rate constants while the Control Panel is hidden.
Log10 Timescale: Data and simulations can now be graphed on a log(10) timescale, which is useful when examining processes that occur over a wider range of times.

Software Download Options

Kinetic Explorer Demo Movie Download Options