KinTek Explorer Professional Software

 

Here you will find the latest of the versions of the KinTek Global Kinetics Explorer

Version 2.0 Zipped files
 

New Features in Version 2.0 of KinTek Kinetic Explorer

  
  FitSpace Explorer: Given the power and ease of use of KinTek Explorer, it is too easy to enter an overly complex model and often difficult to evaluate whether the model and the rate constants are actually determined by the data. Conventional error analysis fails miserably to notify you when your model is under-constrained. Therefore, it is difficult to evaluate the extent to which the fit and the model are constrained by the data especially when fitting multiple parameters to multiple data sets simultaneously. FitSpace Explorer solves these problems by exploring the range over which parameters can vary and still achieve a good fit to the data. This analysis provides more realistic estimates of errors on fitted parameters than are obtained by conventional nonlinear regression covariance analysis FitSpace Example
Confidence contour showing dependence of sum square error on parameters.		  
  No more Reverse Polish Notation: Entry of output expressions now uses the more familiar infix notation. The first time you load an old mechanism file created under Version 1, you will be required to convert your output expression to infix notation. This is explained in more detail under Experiment Editor. Rate vs Concentration Plot: You can fit your data to analytic functions in the old-fashioned way and if you have a series of traces collected at several concentrations, you can click on Rate v. Conc and see the a graph of the concentration dependence of the observed rates. This is useful in revealing patterns in the data that suggest the underlying mechanism.
Dimer formation: Version 1 did not properly handle mass balance of reactions involving dimerization. The current release resolves these issues.
Faster Execution: Improvements in the integrator make fitting and scrolling more than 10-fold faster! Also, the user no longer enters the number of points to simulate; rather, the integrator optimizes the step-size during simulation.
Double Precision: All calculations are now done in double precision (64-bit).
Two papers describing the use of the KinTek Explorer and Fitspace Explorer have been submitted to Analytical Biochemistry, where the theory behind Fitspace Explorer is explained in more detail than provided here.